\begin{tabular}{llll}
Rank & Pair & Description & NN \\
\hline
\bfseries 1 & \bfseries D00574 & \bfseries Aminoglutethimide & 0.296 \\
\bfseries\indb{C}   & \bfseries hsa1589 & \bfseries CYP21A2: cytochrome P450,&\\
     &&\bfseries family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) & 0.255 \\
\hline
\bfseries 2 & \bfseries D00542 & \bfseries Halothane & 0.667 \\
\bfseries\indb{D}   & \bfseries hsa1571 & \bfseries CYP2E1: cytochrome P450, family 2,&\\
     &&\bfseries subfamily E, polypeptide 1 (EC:1.14.14.1) & 0.607 \\
\hline
\bfseries 3 & \bfseries D00139 & \bfseries Methoxsalen & 0.310 \\
\bfseries\indb{D}   & \bfseries hsa1543 & \bfseries CYP1A1: cytochrome P450, family 1,&\\
     &&\bfseries subfamily A, polypeptide 1 (EC:1.14.14.1) & 0.735 \\
\hline
 4 &  D00437 &  Nifedipine & 0.237 \\
   &  hsa1585 &  CYP11B2: cytochrome P450,&\\
     && family 11, subfamily B, polypeptide 2 (EC:1.14.15.4 1.14.15.5) & 0.930 \\
\hline
\bfseries 5 & \bfseries D00437 & \bfseries Nifedipine & 0.237 \\
\bfseries\indb{D}   & \bfseries hsa1559 & \bfseries CYP2C9: cytochrome P450, family 2,&\\
     &&\bfseries subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) & 0.924 \\
\hline
 6 &  D00528 &  Caffeine & 0.250 \\
   &  hsa1549 &  CYP2A7: cytochrome P450, family 2,&\\
     && subfamily A, polypeptide 7 (EC:1.14.14.1) & 0.944 \\
\hline
 7 &  D00691 &  Dyphylline & 0.684 \\
   &  hsa5152 &  PDE9A: phosphodiesterase 9A (EC:3.1.4.35) & 0.171 \\
\hline
 8 &  D00410 &  Metyrapone & 0.345 \\
   &  hsa1583 &  CYP11A1: cytochrome P450,&\\
     && family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) & 0.335 \\
\hline
 9 &  D03670 &  Deferoxamine & 0.140 \\
   &  hsa1579 &  CYP4A11: cytochrome P450,&\\
     && family 4, subfamily A, polypeptide 11 (EC:1.14.15.3) & 0.947 \\
\hline
 10 &  D00691 &  Dyphylline & 0.684 \\
   &  hsa8654 &  PDE5A: phosphodiesterase 5A,&\\
     && cGMP-specific (EC:3.1.4.35) & 0.217 \\
\hline
 11 &  D00126 &  Ibuprofen & 0.524 \\
   &  hsa247 &  ALOX15B: arachidonate 15-lipoxygenase,&\\
     && type B (EC:1.13.11.33) & 0.468 \\
\hline
 12 &  D00410 &  Metyrapone & 0.345 \\
   &  hsa1543 &  CYP1A1: cytochrome P450, family 1,&\\
     && subfamily A, polypeptide 1 (EC:1.14.14.1) & 0.735 \\
\hline
\bfseries 13 & \bfseries D00449 & \bfseries Sulfinpyrazone & 0.677 \\
\bfseries\indb{C}   & \bfseries hsa5742 & \bfseries PTGS1: prostaglandin-endoperoxide&\\
     &&\bfseries synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) & 0.640 \\
\hline
\bfseries 14 & \bfseries D05458 & \bfseries Phentermine & 0.562 \\
\bfseries\indb{D}   & \bfseries hsa4128 & \bfseries MAOA & 0.748 \\
\hline
\bfseries 15 & \bfseries D00947 & \bfseries Linezolid & 0.500 \\
\bfseries\indb{C}   & \bfseries hsa4129 & \bfseries MAOB: monoamine oxidase B (EC:1.4.3.4) & 0.748 \\
\hline
\bfseries 16 & \bfseries D00410 & \bfseries Metyrapone & 0.345 \\
\bfseries\indb{D}   & \bfseries hsa1585 & \bfseries CYP11B2: cytochrome P450,&\\
     &&\bfseries family 11, subfamily B, polypeptide 2 (EC:1.14.15.4 1.14.15.5) & 0.930 \\
\hline
 17 &  D00126 &  Ibuprofen & 0.524 \\
   &  hsa246 &  ALOX15: arachidonate 15-lipoxygenase&\\
     && (EC:1.13.11.33) & 0.668 \\
\hline
\bfseries 18 & \bfseries D00691 & \bfseries Dyphylline & 0.632 \\
\bfseries\indb{D}   & \bfseries hsa5150 & \bfseries PDE7A: phosphodiesterase 7A (EC:3.1.4.17) & 0.600 \\
\hline
\bfseries 19 & \bfseries D00537 & \bfseries Topiramate & 0.265 \\
\bfseries\indb{C}   & \bfseries hsa759 & \bfseries CA1: carbonic anhydrase I (EC:4.2.1.1) & 0.602 \\
\hline
\bfseries 20 & \bfseries D00097 & \bfseries Salicylic acid & 0.750 \\
\bfseries\indb{D}   & \bfseries hsa5743 & \bfseries PTGS2: prostaglandin-endoperoxide&\\
     &&\bfseries synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) & 0.640 \\
\hline
 21 &  D03670 &  Deferoxamine & 0.140 \\
   &  hsa9420 &  CYP7B1: cytochrome P450, family 7,&\\
     && subfamily B, polypeptide 1 (EC:1.14.13.100) & 0.360 \\
\hline
 22 &  D00691 &  Dyphylline & 0.632 \\
   &  hsa50940 &  PDE11A: phosphodiesterase 11A&\\
     && (EC:3.1.4.35 3.1.4.17) & 0.265 \\
\hline
 23 &  D00703 &  Ethinamate & 0.100 \\
   &  hsa762 &  CA4: carbonic anhydrase IV (EC:4.2.1.1) & 0.232 \\
\hline
 24 &  D03670 &  Deferoxamine & 0.140 \\
   &  hsa51302 &  CYP39A1 & 0.157 \\
\hline
 25 &  D00401 &  Methimazole & 0.385 \\
   &  hsa8288 &  EPX: eosinophil peroxidase (EC:1.11.1.7) & 0.701 \\
\hline
 26 &  D00501 &  Pentoxifylline & 0.600 \\
   &  hsa50940 &  PDE11A: phosphodiesterase 11A&\\
     && (EC:3.1.4.35 3.1.4.17) & 0.320 \\
\hline
 27 &  D00131 &  Disulfiram & 0.152 \\
   &  hsa8854 &  ALDH1A2: aldehyde dehydrogenase 1&\\
     && family, member A2 (EC:1.2.1.36) & 0.744 \\
\hline
 28 &  D03670 &  Deferoxamine & 0.064 \\
   &  hsa4353 &  MPO & 0.701 \\
\hline
 29 &  D00528 &  Caffeine & 0.800 \\
   &  hsa50940 &  PDE11A: phosphodiesterase 11A&\\
     && (EC:3.1.4.35 3.1.4.17) & 0.320 \\
\hline
\bfseries 30 & \bfseries D00401 & \bfseries Methimazole & 0.385 \\
\bfseries\indb{C}   & \bfseries hsa4025 & \bfseries LPO: lactoperoxidase (EC:1.11.1.7) & 0.510 \\
\hline
\bfseries 31 & \bfseries D02441 & \bfseries Ethoxzolamide & 0.500 \\
\bfseries\indb{C,D}   & \bfseries hsa760 & \bfseries CA2: carbonic anhydrase II (EC:4.2.1.1) & 0.602 \\
\hline
 32 &  D00501 &  Pentoxifylline & 0.600 \\
   &  hsa5150 &  PDE7A: phosphodiesterase 7A (EC:3.1.4.17) & 0.600 \\
\hline
 33 &  D01665 &  Voglibose & 0.455 \\
   &  hsa279 &  AMY2A: amylase, alpha 2A (pancreatic)&\\
     && (EC:3.2.1.1) & 0.013 \\
\hline
 34 &  D00118 &  Naproxen & 0.565 \\
   &  hsa3906 &  LALBA: lactalbumin, alpha- (EC:2.4.1.22) & 0.033 \\
\hline
 35 &  D00043 &  Isoflurophate & 0.000 \\
   &  hsa1990 &  CELA1: chymotrypsin-like elastase&\\
     && family, member 1 (EC:3.4.21.36) & 0.552 \\
\hline
 36 &  D00528 &  Caffeine & 0.800 \\
   &  hsa5150 &  PDE7A: phosphodiesterase 7A (EC:3.1.4.17) & 0.600 \\
\hline
 37 &  D00184 &  Cyclosporine & 0.222 \\
   &  hsa85313 &  PPIL4: peptidylprolyl isomerase&\\
     && (cyclophilin)-like 4 (EC:5.2.1.8) & 0.030 \\
\hline
 38 &  D00141 &  Indomethacin & 0.517 \\
   &  hsa3906 &  LALBA: lactalbumin, alpha- (EC:2.4.1.22) & 0.033 \\
\hline
 39 &  D03670 &  Deferoxamine & 0.140 \\
   &  hsa51004 &  COQ6 & 0.024 \\
\hline
 40 &  D00188 &  Cholecalciferol & 0.812 \\
   &  hsa1594 &  CYP27B1: cytochrome P450,&\\
     && family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) & 0.364 \\
\hline
 41 &  D00041 &  Threonine & 0.778 \\
   &  hsa10295 &  BCKDK & 0.021 \\
\hline
\bfseries 42 & \bfseries D03365 & \bfseries Nicotine & 0.364 \\
\bfseries\indb{C,D}   & \bfseries hsa1548 & \bfseries CYP2A6: cytochrome P450, family 2,&\\
     &&\bfseries subfamily A, polypeptide 6 (EC:1.14.14.1) & 0.945 \\
\hline
 43 &  D03433 &  Celgosivir hydrochloride & 0.435 \\
   &  hsa279 &  AMY2A: amylase, alpha 2A (pancreatic)&\\
     && (EC:3.2.1.1) & 0.013 \\
\hline
 44 &  D00184 &  Cyclosporine & 0.222 \\
   &  hsa53938 &  PPIL3: peptidylprolyl isomerase&\\
     && (cyclophilin)-like 3 (EC:5.2.1.8) & 0.063 \\
\hline
 45 &  D01425 &  Lopinavir & 0.333 \\
   &  hsa1586 &  CYP17A1: cytochrome P450,&\\
     && family 17, subfamily A, polypeptide 1 (EC:1.14.99.9) & 0.266 \\
\hline
 46 &  D00533 &  Oxcarbazepine & 0.519 \\
   &  hsa1559 &  CYP2C9: cytochrome P450, family 2,&\\
     && subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) & 0.924 \\
\hline
 47 &  D00039 &  Valine & 0.700 \\
   &  hsa587 &  BCAT2: branched chain amino-acid&\\
     && transaminase 2, mitochondrial (EC:2.6.1.42) & 0.576 \\
\hline
 48 &  D00593 &  Glimepiride & 0.405 \\
   &  hsa1557 &  CYP2C19: cytochrome P450,&\\
     && family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) & 0.924 \\
\hline
 49 &  D01118 &  Profenamine hydrochloride & 0.452 \\
   &  hsa43 &  ACHE: acetylcholinesterase (EC:3.1.1.7) & 0.534 \\
\hline
\bfseries 50 & \bfseries D00454 & \bfseries Olanzapine & 0.607 \\
\bfseries\indb{D}   & \bfseries hsa1576 & \bfseries CYP3A4: cytochrome P450, family 3,&\\
     &&\bfseries subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32) & 0.131 \\
\hline
\end{tabular}
